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Press enter to search. Latest Issue. Previous Issue. Clinical correspondence. Editorial Board. Clinical Correspondence. Vol No 17 December Gee cdhb. View PDF Version. Subscriber Content The full contents of this pages only available to subscribers. This Issue. Inappropriate trace element testing in the Auckland region. The supplement users reacted with some incredulity and a lot of stockpiling to the impending ban on DMAA.

DMAA is banned by most sporting bodies for use by athletes, but that is because it is a stimulant, and stimulants in general are banned by sporting bodies. Yes, borage suspected hepatotoxicity. Merely looking like another compound is no guarantee that something will have the same properties as that compound, as drug companies have learnt to their cost, even small changes in structure can have big effects on how fast a substance breaks down, or activates biochemical pathways. Data on the potency and mechanism of action of DMAA is hard to come by.

You have to go wayback in time to find some of this data. Experimental administration of DMAA to humans at levels consistent with supplement use, alone, or together with caffeine which is in a lot of DMAA containing supplements , shows DMAA can cause a modest increase in blood pressure taken as a one off dose.

If you take it for 10 days or more blood pressure appears to return to normal doi: S, doi: Outside of these controlled experiments DMAA has been associated with a number of adverse events, such as panic attacks, seizures, stress-induced cardiomyopathy, and is suspected to be involved in two deaths.

While these reports are consistent with the known pharmacological effects of DMAA, causation has not been established in these cases, especially as DMAA is often consumed with high doses of caffeine, which has also been associated with similar adverse effects. Given the relatively few reported events and the widespread use of these supplements, we might suspect the frequency is low.

But we also know that adverse events are under-reported, and the exact number or even ball-park number of users is unclear. When he arrived, he was immediately given a brain scan, which revealed a large cerebral hemorrhage. Subsequent studies could not find any biological cause beyond the DMAA in his blood.

The man suffered long-term brain damage regarding his memory and abstract reasoning. He also suffered mild impairments of right hand coordination and speech. The New Zealand government was also aware of a 45 year-old man who suffered a stroke. The man had DMAA in his bloodstream. They are also aware of cases of serious headaches, vomiting, and nausea in some users. The evidence linking DMAA to the geranium plant is based on one Chinese report that was published in a non-peer-reviewed technical journal in The authors of the report took dried botanical samples and ran them through a gas-spectrometer.

A machine analyzed the gas and automatically identified 40 compounds, including DMAA. The results of this report have never been repeated, though several have tried.



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